Lion’s Mane Mushroom (Hericium erinaceus) and Nerve Regeneration

The unique flavor of the gourmet mushroom Lion’s Mane (Hericium erinaceus) is often compared to either lobster or shrimp. And modern science is now discovering that not only is it a culinary delicacy but it may also possess some unique medicinal properties, with its ability to stimulate nerve and myelin regeneration. [150, 151] In the book Mycelium Running, foremost American medicinal mushroom expert Paul Stamets suggests this may make Hericium erinaceus useful in a large number of neurological conditions, from multiple sclerosis and muscular dystrophy to Alzheimer’s and dementia. [134]

In the wild, Lion’s Mane Mushroom (Hericium erinaceus) grows on hardwood trees, especially oak, sycamore, maple, walnut and beech. It can be found throughout the temperate areas of the world, from North America and Europe to Japan and China.

The active compounds that have received the most attention for their nerve regenerating properties are named erinacines, a series of low molecular weight molecules that are able to pass through the blood brain barrier – an essential attribute for any medicinal compound expected to be able to effect healing on myelin or nerve tissue. [152, 153, 154]

Two Japanese patents exist relating to Hericium erinaceus extracts; one from the 1990’s for an extraction process of these compounds yielding an extract known as “Nerve Growth Stimulant Factor.” [150, 151] A more recent one from 2004 is for a water extract of Hericium erinaceus, also used for its nerve regenerating properties. [155]

Although recent research on Hericium erinaceus extract has focused on its powerful effect on healing nerve tissue, in Traditional Chinese Medicine Lion’s Mane Mushroom was used primarily for stomach conditions and cancers of the digestive organs.

Two modern studies have confirmed this ancient wisdom. One done in 1985 showed positive results for treating atrophic gastritis. Another conducted a decade later, in 1995, showed some ameliorating effect on hepatoma, with a marked life extension of treated patients. [156]

To conclude, some additional areas where modern medical research has indicated that Hericium erinaceus extract may have a therapeutic effect include: Immune support [157]; inflammation [134]; antimicrobial against Aspergillus and Candida [158]; anti-tumoral [159]; stomach cancer. [134]

Note: The statements on this page have not been evaluated by the Food and Drug Administration. This article is not intended to diagnose, treat, cure or prevent any disease. Never use any medicinal mushroom or herb without prior approval by medical doctor.

Credit to Paul Stamets for research and source material.

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